Endocrine Abstracts

Bone marrow adipose tissue (BMAT) accounts for up to 70% of bone marrow volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases in diverse clinical conditions, including ageing, osteoporosis, obesity/diabetes, glucocorticoid treatment, cancer therapy and, strikingly, during caloric restriction. Many of these conditions are also associated with bone loss and increased fracture risk, and therefore it has been suggested that BMAT might directly i...

Introduction: White adipose tissue (WAT) and brown adipose tissue (BAT) are key regulators of systemic metabolic function. Bone marrow adipose tissue (BMAT) accounts for 10% of total adipose mass in healthy humans and therefore can be considered a third major adipose subtype. However, it is unclear if BMAT contributes to systemic energy homeostasis.Objectives: Assess [18F]-Fluorodeoxyglucose (FDG) uptake into bone and the marrow cavity (MC) fo...

Background: Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass in healthy humans and further increases in diverse clinical conditions, including obesity/diabetes, osteoporosis and following caloric restriction (CR). However, why BMAT increases during CR remains unknown. One possibility is that this is mediated by glucocorticoid (GC) excess. GC action on target tissues depends on circulating and intracellular concentrations of t...

Caloric restriction (CR) is a nutritional intervention that reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased fat mass and improved insulin sensitivity, play an important role in its broader health benefits, yet many aspects of the CR response remain poorly understood. In particular, sex differences in metabolic function are increasingly well recognised, but the extent and basis of sex differences i...